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steiger_pval is NaN #585

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amaa11 opened this issue Jan 22, 2025 · 1 comment
Open

steiger_pval is NaN #585

amaa11 opened this issue Jan 22, 2025 · 1 comment

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@amaa11
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amaa11 commented Jan 22, 2025

Dear all,

I am really thankful for such amazing tool to run MR analysis.
I have run thousands of analyses and for some of them the steiger_pval is NaN (the one generated in the html file)
When I checked, I found that the snp_r2.exposure is more than one which should not be. right?
Any help why the value of snp_r2.exposure more than one? and does that cause that the steiger_pval is NaN
I checked for effect allele frequency of the exposure and they are between 0 and 1.
I also checked to see if there are extreme values for the beta and SE of the exposure, but could not find.
Here is the description of the beta, se and eaf.

beta.exposure se.exposure eaf.exposure
count 211.000000 211.000000 211.000000
mean 0.002583 0.013032 0.258639
std 0.193913 0.007551 0.226196
min -0.869519 0.006504 0.008149
25% -0.125157 0.007973 0.069125
50% 0.066152 0.009811 0.190659
75% 0.119111 0.014993 0.388458
max 0.467316 0.044810 0.985219

@TheodoreLevitt
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Hii Ama11, can you work with this package. COuld you please share an example code because I am facing error.

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