Authorisation error when accepting MRBase Data Access Agreement

[r1v3rnov4]

When I try to accept the data access agreement, I am redirected to this notice.
This prevents me from using the MRBase web app.

Any ways to get around this?

[remlapmot]

If this is still a problem could you try using the R code instead of the app. There is example R code in the vignettes listed on our website here

https://mrcieu.github.io/TwoSampleMR/articles/index.html

An analysis in an R script would be as follows (you need to change the exposure and outcome data for your research question).

install.packages('remotes')
remotes::install_github('MRCIEU/TwoSampleMR')
library(TwoSampleMR)

bmi_exp_dat <- extract_instruments(outcomes = 'ieu-a-2')
chd_out_dat <- extract_outcome_data(snps = bmi_exp_dat$SNP, outcomes = 'ieu-a-7')
dat <- harmonise_data(bmi_exp_dat, chd_out_dat)

res <- mr(dat)

mr(dat, method_list = c("mr_egger_regression", "mr_ivw"))

mr_heterogeneity(dat)

mr_pleiotropy_test(dat)

p1 <- mr_scatter_plot(res, dat)
p1[[1]]

res_single <- mr_singlesnp(dat)

p2 <- mr_forest_plot(res_single)
p2[[1]]

p4 <- mr_funnel_plot(res_single)
p4[[1]]