From ab47f4578dde95694f93d8f9774405cb07f0e121 Mon Sep 17 00:00:00 2001
From: zhenxian <920596906@qq.com>
Date: Sat, 4 Sep 2021 21:41:35 +0800
Subject: [PATCH] Update README.md

update readme
---
 README.md | 5 ++++-
 1 file changed, 4 insertions(+), 1 deletion(-)

diff --git a/README.md b/README.md
index 0225e88..e090165 100644
--- a/README.md
+++ b/README.md
@@ -26,8 +26,11 @@ Clair3 is the 3<sup>rd</sup> generation of [Clair](https://github.com/HKU-BAL/Cl
 
 We are actively fixing bugs and issues in Clair3 reported by users.
 
+*v0.1-r6 (Sep 4)* : 1. Reduced memory footprint at the `SortVcf` stage([#45](https://github.com/HKU-BAL/Clair3/issues/45)). 2. Reduced `ulimit -n` (number of files simultaneously opened) requirement ([#45](https://github.com/HKU-BAL/Clair3/issues/45), [#47](https://github.com/HKU-BAL/Clair3/issues/47)). 3. Added Clair3-Illumina package in bioconda([#42](https://github.com/HKU-BAL/Clair3/issues/42)).
+
 *v0.1-r5 (July 19)* : 1. Modified data generator in model training to avoid memory exhaustion and unexpected segmentation fault by Tensorflow (contributor @[ftostevin-ont](https://github.com/ftostevin-ont) ). 2. Simplified dockerfile workflow to reuse container caching (contributor @[amblina](https://github.com/amblina)). 3. Fixed ALT output for reference calls (contributor @[wdecoster](https://github.com/wdecoster)). 4. Fixed a bug in multi-allelic AF computation (AF of [ACGT]Del variants was wrong before r5). 5. Added AD tag to the GVCF output. 6. Added the `--call_snp_only` option to only call SNP only ([#40](https://github.com/HKU-BAL/Clair3/issues/40)). 7. Added pileup and full-alignment output validity check to avoid workflow crashing ([#32](https://github.com/HKU-BAL/Clair3/issues/32), [#38](https://github.com/HKU-BAL/Clair3/issues/38)).
 
+
 *v0.1-r4 (June 28)* : 1. Install via [bioconda](https://github.com/HKU-BAL/Clair3#option-3--bioconda). 2. Added an ONT Guppy2 model to the images (`ont_guppy2`). Click [here](https://github.com/HKU-BAL/Clair3/blob/main/docs/guppy2.md) for more benchmarking results. **The results show you have to use the Guppy2 model for Guppy2 or earlier data**. 3. Added [google colab notebooks](https://github.com/HKU-BAL/Clair3/blob/main/colab) for quick demo. 4. Fixed a bug when there are too few variant candidates ([#28](https://github.com/HKU-BAL/Clair3/issues/28)).
 
 *v0.1-r3 (June 9)* : 1. Added `ulimit -u` (max user processes) check (lowers the `THREADS` if the resource is insufficient) and automatic retries on failed jobs ([#20](https://github.com/HKU-BAL/Clair3/issues/20), [#23](https://github.com/HKU-BAL/Clair3/issues/23), [#24](https://github.com/HKU-BAL/Clair3/issues/24)). 2. Added an ONT Guppy5 model to the images (`ont_guppy5`). Click [here](docs/guppy5.md) for more benchmarks on the Guppy5 model and data.
@@ -501,4 +504,4 @@ Download models from [here](http://www.bio8.cs.hku.hk/clair3/clair3_models/) or
 
 Clair3 supports both VCF and GVCF output formats. Clair3 uses VCF version 4.2 specifications. Specifically, Clair3 adds a `P` INFO tag to the results called using a pileup model, and a `F` INFO tag to the results called using a full-alignment model.
 
-Clair3 outputs a GATK-compatible GVCF format that passes GATK's `ValidateVariants` module. Different from DeepVariant that uses `<*>` to represent any possible alternative allele, Clair3 uses `<NON_REF>`, the same as GATK.
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+Clair3 outputs a GATK-compatible GVCF format that passes GATK's `ValidateVariants` module. Different from DeepVariant that uses `<*>` to represent any possible alternative allele, Clair3 uses `<NON_REF>`, the same as GATK.