diff --git a/var/spack/repos/builtin/packages/py-nanobind/package.py b/var/spack/repos/builtin/packages/py-nanobind/package.py
index 5ea6ca685eb448..1147671f6f7533 100644
--- a/var/spack/repos/builtin/packages/py-nanobind/package.py
+++ b/var/spack/repos/builtin/packages/py-nanobind/package.py
@@ -23,6 +23,12 @@ class PyNanobind(PythonPackage):
     license("BSD-3-Clause")
 
     version("master", branch="master", submodules=True)
+    version(
+        "2.2.0", tag="v2.2.0", commit="784efa2a0358a4dc5432c74f5685ee026e20f2b6", submodules=True
+    )
+    version(
+        "2.1.0", tag="v2.1.0", commit="9641bb7151f04120013b812789b3ebdfa7e7324f", submodules=True
+    )
     version(
         "2.0.0", tag="v2.0.0", commit="8d7f1ee0621c17fa370b704b2100ffa0243d5bfb", submodules=True
     )
@@ -57,12 +63,15 @@ class PyNanobind(PythonPackage):
     depends_on("cxx", type="build")  # generated
 
     depends_on("python@3.8:", type=("build", "run"))
-    depends_on("py-setuptools@42:", type="build")
-    depends_on("py-scikit-build", type="build")
-    depends_on("py-typing-extensions", when="@2:", type="build")
 
-    depends_on("cmake@3.17:", type="build")
-    depends_on("ninja", type="build")
+    depends_on("py-setuptools@42:", when="@:2.0", type="build")
+    depends_on("py-scikit-build", when="@:2.0", type="build")
+    depends_on("py-typing-extensions", when="@2.0", type="build")
+    depends_on("ninja", when="@2.0", type="build")
+    depends_on("cmake@3.17:", when="@:2.0", type="build")
+
+    depends_on("py-scikit-build-core+pyproject@0.9:", when="@2.1", type="build")
+    depends_on("py-scikit-build-core+pyproject@0.10:", when="@2.2:", type="build")
 
     @property
     def cmake_prefix_paths(self):