diff --git a/lldb/packages/Python/lldbsuite/test/tools/lldb-server/gdbremote_testcase.py b/lldb/packages/Python/lldbsuite/test/tools/lldb-server/gdbremote_testcase.py
index d6cb68f55bf296..cbe430c92fa7fb 100644
--- a/lldb/packages/Python/lldbsuite/test/tools/lldb-server/gdbremote_testcase.py
+++ b/lldb/packages/Python/lldbsuite/test/tools/lldb-server/gdbremote_testcase.py
@@ -1410,7 +1410,17 @@ def read_register_values(self, reg_infos, endian, thread_id=None):
             p_response = context.get("p_response")
             self.assertIsNotNone(p_response)
             self.assertTrue(len(p_response) > 0)
-            self.assertFalse(p_response[0] == "E")
+
+            # on x86 Darwin, 4 GPR registers are often
+            # unavailable, this is expected and correct.
+            if (
+                self.getArchitecture() == "x86_64"
+                and self.platformIsDarwin()
+                and p_response[0] == "E"
+            ):
+                values[reg_index] = 0
+            else:
+                self.assertFalse(p_response[0] == "E")
 
             values[reg_index] = unpack_register_hex_unsigned(endian, p_response)
 
diff --git a/lldb/test/API/commands/register/register/register_command/TestRegisters.py b/lldb/test/API/commands/register/register/register_command/TestRegisters.py
index 0b80a09534371e..99290e02cd2b04 100644
--- a/lldb/test/API/commands/register/register/register_command/TestRegisters.py
+++ b/lldb/test/API/commands/register/register/register_command/TestRegisters.py
@@ -58,6 +58,13 @@ def test_register_commands(self):
             # could not be read.  This is expected.
             error_str_matched = True
 
+        if self.getArchitecture() == "x86_64" and self.platformIsDarwin():
+            # debugserver on x86 will provide ds/es/ss/gsbase when the
+            # kernel provides them, but most of the time they will be
+            # unavailable.  So "register read -a" will report that
+            # 4 registers were unavailable, it is expected.
+            error_str_matched = True
+
         self.expect(
             "register read -a",
             MISSING_EXPECTED_REGISTERS,