diff --git a/.gitlab/benchmarks/microbenchmarks.yml b/.gitlab/benchmarks/microbenchmarks.yml
index 8c78d05ca16..a5b60a18d3f 100644
--- a/.gitlab/benchmarks/microbenchmarks.yml
+++ b/.gitlab/benchmarks/microbenchmarks.yml
@@ -163,7 +163,6 @@ microbenchmarks:
         - "packages_update_imported_dependencies"
         - "telemetry_add_metric"
         - "startup"
-        - "ddtrace_run"
 
 "microbenchmarks flaky":
   extends: .benchmarks
diff --git a/benchmarks/ddtrace_run/config.yaml b/benchmarks/ddtrace_run/config.yaml
deleted file mode 100644
index 28f62ea5f78..00000000000
--- a/benchmarks/ddtrace_run/config.yaml
+++ /dev/null
@@ -1,46 +0,0 @@
-auto_baseline: &defaults
-  ddtrace_run: "true"
-  http: "true"
-  runtimemetrics: "false"
-  telemetry: "false"
-  tracing: "false"
-  profiling: "false"
-  appsec: "false"
-
-manual_baseline:
-  <<: *defaults
-  ddtrace_run: "false"
-
-auto_runtimemetrics:
-  <<: *defaults
-  runtimemetrics: "true"
-
-auto_appsec:
-  <<: *defaults
-  appsec: "true"
-
-auto_baseline_disable_http:
-  <<: *defaults
-  http: "false"
-
-auto_telemetry:
-  <<: *defaults
-  telemetry: "true"
-
-auto_profiling:
-  <<: *defaults
-  profiling: "true"
-
-auto_tracing:
-  <<: *defaults
-  tracing: "true"
-
-auto_tracing_telemetry:
-  <<: *defaults
-  tracing: "true"
-  telemetry: "true"
-
-auto_tracing_appsec:
-  <<: *defaults
-  tracing: "true"
-  appsec: "true"
diff --git a/benchmarks/ddtrace_run/scenario.py b/benchmarks/ddtrace_run/scenario.py
deleted file mode 100644
index 983d2c7e870..00000000000
--- a/benchmarks/ddtrace_run/scenario.py
+++ /dev/null
@@ -1,68 +0,0 @@
-import os
-import subprocess
-import sys
-
-import bm
-
-
-class DDtraceRun(bm.Scenario):
-    ddtrace_run: bool
-    http: bool
-    runtimemetrics: bool
-    telemetry: bool
-    profiling: bool
-    appsec: bool
-    tracing: bool
-
-    def run(self):
-        # setup subprocess environment variables
-        env = os.environ.copy()
-        env["DD_RUNTIME_METRICS_ENABLED"] = str(self.runtimemetrics)
-        env["DD_APPSEC_ENABLED"] = str(self.appsec)
-
-        # initialize subprocess args
-        subp_cmd = []
-        code = "import ddtrace; ddtrace._monkey._patch_all()\n"
-        if self.ddtrace_run:
-            subp_cmd = ["ddtrace-run"]
-            code = ""
-
-        if self.http:
-            # mock requests to the trace agent before starting services
-            env["DD_TRACE_API_VERSION"] = "v0.4"
-            code += """
-import httpretty
-from ddtrace.trace import tracer
-from ddtrace.internal.telemetry import telemetry_writer
-
-httpretty.enable(allow_net_connect=False)
-httpretty.register_uri(httpretty.PUT, '%s/%s' % (tracer.agent_trace_url, 'v0.5/traces'))
-httpretty.register_uri(httpretty.POST, '%s/%s' % (tracer.agent_trace_url, telemetry_writer._client._endpoint))
-# profiler will collect snapshot during shutdown
-httpretty.register_uri(httpretty.POST, '%s/%s' % (tracer.agent_trace_url, 'profiling/v1/input'))
-"""
-
-        if self.telemetry:
-            code += "telemetry_writer.enable()\n"
-
-        if self.tracing:
-            code += "span = tracer.trace('test-x', service='bench-test'); span.finish()\n"
-
-        if self.profiling:
-            code += """
-import time
-import ddtrace.profiling.auto
-
-start = time.perf_counter()
-while time.perf_counter() - start < 1.0:
-    pass  # Busy wait
-"""
-
-        # stage code for execution in a subprocess
-        subp_cmd += [sys.executable, "-c", code]
-
-        def _(loops):
-            for _ in range(loops):
-                subprocess.check_output(subp_cmd, env=env)
-
-        yield _
diff --git a/benchmarks/startup/config.yaml b/benchmarks/startup/config.yaml
index c7603fc6c29..7e90a84e4ce 100644
--- a/benchmarks/startup/config.yaml
+++ b/benchmarks/startup/config.yaml
@@ -1,5 +1,7 @@
 baseline: &defaults
   env: {}
+  ddtrace_run: false
+  send_span: false
   import_ddtrace: false
   import_ddtrace_auto: false
   import_flask: false
@@ -32,3 +34,29 @@ import_ddtrace_auto_django:
   <<: *defaults
   import_ddtrace_auto: true
   import_django: true
+ddtrace_run:
+  <<: *defaults
+  ddtrace_run: true
+ddtrace_run_appsec:
+  <<: *defaults
+  env: {"DD_APPSEC_ENABLED": "true"}
+  ddtrace_run: true
+ddtrace_run_profiling:
+  <<: *defaults
+  env: {"DD_PROFILING_ENABLED": "true"}
+  ddtrace_run: true
+ddtrace_run_telemetry_enabled:
+  <<: *defaults
+  env: {"_DD_INSTRUMENTATION_TELEMETRY_TESTS_FORCE_APP_STARTED": "true"}
+  ddtrace_run: true
+ddtrace_run_telemetry_disabled:
+  <<: *defaults
+  env: {"DD_INSTRUMENTATION_TELEMETRY_ENABLED": "false", "_DD_INSTRUMENTATION_TELEMETRY_TESTS_FORCE_APP_STARTED": "false"}
+  ddtrace_run: true
+ddtrace_run_send_span:
+  <<: *defaults
+  send_span: true
+ddtrace_run_runtime_metrics:
+  <<: *defaults
+  env: {"DD_RUNTIME_METRICS_ENABLED": "true"}
+  ddtrace_run: true
\ No newline at end of file
diff --git a/benchmarks/startup/scenario.py b/benchmarks/startup/scenario.py
index 522f92dc5f3..1c1bc2f2801 100644
--- a/benchmarks/startup/scenario.py
+++ b/benchmarks/startup/scenario.py
@@ -8,8 +8,10 @@
 class Startup(bm.Scenario):
     import_ddtrace: bool
     import_ddtrace_auto: bool
+    ddtrace_run: bool
     import_flask: bool
     import_django: bool
+    send_span: bool
     env: str
 
     def run(self):
@@ -33,8 +35,15 @@ def run(self):
             # `import django` doesn't really do anything, `django.core.management` is what `manage.py` uses
             commands.append("import django.core.management")
 
+        if self.send_span:
+            commands.append("from ddtrace.trace import tracer")
+            commands.append("tracer.trace('test-x', service='bench-test').finish()")
+
         args = ["python", "-c"] + [";".join(commands)]
 
+        if self.ddtrace_run:
+            args = ["ddtrace-run"] + args
+
         def _(loops: int):
             for _ in range(loops):
                 subprocess.check_call(args=args, env=env)