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UK Biobank Tabular Preprocessing

This software is intended to assist to transforming the raw tabular data (*tab) files supplied by the UKBB as raw data into a format more suitable for analysis in python/R/MATLAB

Preparation

First the UKBB supplied ultra-wide format must be coerced into a long format:

$ awk -f ukb_awk/melt_tab.awk current.tab > current.melt.tsv

This processing does not take much RAM, but is IO-bound. The file after this will be significantly smaller, as NAs will be dropped.

This file is usable, but still very large, one may wish to convert to a binary format which includes compression and significantly decreases size, this performs a streaming conversion which also significantly reduces memory requirements:

$ python -c 'import polars as pl; pl.scan_csv("current.melt.tsv", separator="\t",
             dtypes={
                "SubjectID": pl.Int64,
                "FieldID": pl.Int64,
                "InstanceID": pl.Int64,
                "ArrayID": pl.Int64,
                "FieldValue": pl.Utf8,
            },  encoding="utf8-lossy").sink_ipc("current.melt.arrow", compression="zstd")'

Requirements/Dependencies

This package requires at least python 3.9 due to static typing.

The python script requires the polars package for data handling

An PyYAML to load config files.

See requirements.txt for versions.

Extracting data

Now that you have a arrow or tsv file ready, you can write a configuration file to define the data you would like to extract and run the script.

To choose variables, use the UKBB Showcase to collect FieldIDs and Categories

Make a copy of config.template.yaml and set your settings as appropriate, see embedded documentation of the file for details.

You will need the Codings.tsv and Data_Dictionary_Showcase.tsv from UKBB Showcase Accessing Data

UKBB Category tree file (Schema 13), tab-separated from https://biobank.ndph.ox.ac.uk/showcase/schema.cgi?id=13 and UKBB Data field properties file (Schema 1), tab-separated from https://biobank.ndph.ox.ac.uk/showcase/schema.cgi?id=1

Command-line use

And finally run the script, assuming you have the support files in the local directory:

$ python melted_UKBB_extract.py --config-file myconfig.yaml --data-file current.melt.arrow --output-prefix mysubset_

Use inside python

The function extract_UKBB_tabular_data has the following signature:

def extract_UKBB_tabular_data(
    config: Config,
    data_file: str | None = None,
    dictionary_file: str | None = None,
    coding_file: str | None = None,
    verbose: str | None = False,
) -> tuple[pl.DataFrame, pl.DataFrame | None, pl.DataFrame, pl.DataFrame]:

The return signature depends on the config['wide'] setting.

return data, data_wide, dictionary, codings
# Or when wide=False
return data, None, dictionary, codings

The Config class is a TypedDict, which is just a regular dictionary with defined types. This allows us to better document the properties of the dictionary. The properties of this dictionary are provided in config.py. If you want to have autocompletion in your IDE, you can create a config dict as follows:

config: Config = {...}

If you want to load your config from a yaml file, you can do so as follows:

config = load_config('config.template.yaml')

Outputs

The script will use your config file and your --output-prefix to produce subsets of the full tabular data in narrow (and if configured, wide) formats, as well as a filtered version of Coding.tsv and Data_Dictionary_Showcase.tsv describing the data.

Full Script Options

usage: UKBB Data Extractor [-h] --config-file CONFIG_FILE --data-file DATA_FILE [--dictionary-file DICTIONARY_FILE] [--coding-file CODING_FILE] [--category-tree-file CATEGORY_TREE_FILE] [--data-field-prop-file DATA_FIELD_PROP_FILE] --output-prefix OUTPUT_PREFIX [--output-formats [OUTPUT_FORMATS ...]] [-v]

Transforms melted UKBB tabular data into a usable DataFrame for statistical analysis

optional arguments:
  -h, --help            show this help message and exit
  --config-file CONFIG_FILE
                        YAML config file describing how to process UKBB table (default: None)
  --data-file DATA_FILE
                        UKBB melted tabular data (default: None)
  --dictionary-file DICTIONARY_FILE
                        UKBB data dictionary showcase file (default: Data_Dictionary_Showcase.tsv)
  --coding-file CODING_FILE
                        UKBB coding file (default: Codings.tsv)
  --category-tree-file CATEGORY_TREE_FILE
                        UKBB Category tree file (Schema 13), tab-separated from https://biobank.ndph.ox.ac.uk/showcase/schema.cgi?id=13 (default: 13.txt)
  --data-field-prop-file DATA_FIELD_PROP_FILE
                        UKBB Data field properties file (Schema 1), tab-separated from https://biobank.ndph.ox.ac.uk/showcase/schema.cgi?id=1 (default: 1.txt)
  --output-prefix OUTPUT_PREFIX
                        Prefix for output files (default: None)
  --output-formats [OUTPUT_FORMATS ...]
                        Specify list of output file formats from tsv, arrow/feather, parquet, csv (default: ['tsv', 'arrow'])
  -v, --verbose         increase output verbosity (default: False)

TODO

Regarding the return type of extract_UKBB_tabular_data, the function should ideally take a generic parameter for config that will determine the return type based on config['wide']. However, this is not possible in Python 3.10 ad below, as TypedDict cannot inherit from generic types (see this for more info). Once Once Python 3.10 is no longer supported, this function could be updated with a generic type, so that the signature is inferred based on the value passed in for config.